supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Arachidonic Acid
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“Low concentrations of iron and arachidonic acid synergistically interacted with CYP2E1 to produce cell toxicity, suggesting these nutrients may act as priming or sensitizing agents to alcohol-induced liver injury.”
Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1.“Bilirubin was not protective whereas iron catalyzed the AA toxicity.”
“Increased luciferase expression, both basal (2‐ to 3‐fold) and following exposure to ethanol, arachidonic acid (AA), or AA plus iron , was detected in E47 cells with the full‐length but not shorter reporter vectors.”
“ Iron plus arachidonic acid caused loss of viability, increased lipid peroxidation and reactive oxygen species generation, and mitochondrial membrane injury in these cells.”
“The synergistic toxicity of iron and arachidonic acid has been associated with oxidative stress and lipid peroxidation in HepG2 cells that overexpress CYP2E1.”
“Arachidonic acid AA ) in combination with iron (a catalyst of auto-oxidation) leads cells to produce excess reactive species with a change in mitochondrial permeability transition.”
“Addition of various proteasome inhibitors was associated with significant potentiation of the loss of cell viability caused by AA plus iron.”
“Lipid peroxidation was induced in the E47 cells exposed to Fe plus arachidonic acid and the synergistic toxicity was prevented by antioxidants, which also decreased lipid peroxidation.”
“The results presented suggest that low concentrations of Fe and AA can act as priming or sensitizing factors for CYP2E1-induced injury in HepG2 cells, and such interactions may play a role in alcohol-induced liver injury.”
“Treatment of hepatocytes with iron and AA simulated iron overload conditions: iron + AA synergistically amplified cytotoxicity, increasing H(2)O(2) and the mitochondrial permeability transition.”
Efficacy of sauchinone as a novel AMPK-activating lignan for preventing iron-induced oxidative stress and liver injury.“DHI, CD and DHICA (all in the range ….5 mM) were also found to inhibit Fe (II)/EDTA-induced … 0.5 mM arachidonic acid at pH 7.4, as well as MDA formation by iron-promoted degradation ….5 mM 15-hydroperoxy-5,8,11, 13-eicosatetraenoic acid (15-HPETE).”
“In the sugar-fed group, iron induced a significant diminution of arachidonic acid (P<.001) in both female and male rats in comparison with the sugar-fed group without iron.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback