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Last Updated: 2 years ago

Possible Interaction: Arachidonic Acid and Indomethacin

Research Papers that Mention the Interaction

In humans, aspirin and indomethacin significantly blocked arachidonic acid-induced conjunctival injection.
In this study, we investigated the efficacies of the cyclo-oxygenase inhibitors (aspirin, indomethacin , and piroxicam) and the lipoxygenase inhibitors (N-hydroxy-arachidonamide (AH) and phenidone) in reducing ocular inflammation induced by arachidonic acid.
Journal of ocular pharmacology  •  1987  |  View Paper
Both 17-ODYA and miconazole (10(-5) mol/L, a chemically distinct P450 inhibitor) further reduced the dilation to AA in the presence of INDO.
Circulation research  •  1998  |  View Paper
Indomethacin , a cyclooxygenase inhibitor, blocked the emetogenic effects of both arachidonic acid and 2-AG.
The Journal of pharmacology and experimental therapeutics  •  2002  |  View Paper
The production of TXB2/3 by thrombocytes in response to stimulation with AA was inhibited by aspirin, ibuprofen, and indomethacin.
The American journal of physiology  •  1999  |  View Paper
Prostaglandin E2 production by tumour cells was increased in the presence of arachidonic acid and inhibited when indomethacin was present.
Biochemistry and molecular biology international  •  1998  |  View Paper
Indomethacin inhibited concentration-dependent 8-epi-PGF2alpha formation in platelets stimulated with calcium ionophore, arachidonic acid or thrombin.
The Journal of pharmacology and experimental therapeutics  •  1997  |  View Paper
Moreover, the effect of the arachidonic acid species to stimulate fluid secretion was inhibited by treatment with indomethacin , whereas the effect of the cyst fluid was not.
Journal of the American Society of Nephrology : JASN  •  1995  |  View Paper
Arachidonic acid uptake was inhibited by indometacin but not by nordihydroguaiaretic acid, in diabetic as well as in control subjects.
Diabetes research and clinical practice  •  1989  |  View Paper
4) PG synthesis inhibitors such as indomethacin or flurbiprofen block, or partially inhibit, the reduction of IOP produced by epinephrine, para-aminoclonidine, forskolin, vanadate, verapamil, arachidonic acid , and ALT in rabbits, cats, monkeys, and/or humans.
Progress in clinical and biological research  •  1989  |  View Paper
Indomethacin (3-300 microM) inhibited arachidonic acid-induced aggregation in each species, and collagen responses in all except mouse.
Thrombosis research  •  1987  |  View Paper
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