Possible Interaction: Arachidonic Acid and Indomethacin

“In humans, aspirin and indomethacin significantly blocked arachidonic acid-induced conjunctival injection.”

“In this study, we investigated the efficacies of the cyclo-oxygenase inhibitors (aspirin, indomethacin , and piroxicam) and the lipoxygenase inhibitors (N-hydroxy-arachidonamide (AH) and phenidone) in reducing ocular inflammation induced by arachidonic acid.”

“Both 17-ODYA and miconazole (10(-5) mol/L, a chemically distinct P450 inhibitor) further reduced the dilation to AA in the presence of INDO.”

“ Indomethacin , a cyclooxygenase inhibitor, blocked the emetogenic effects of both arachidonic acid and 2-AG.”

“The production of TXB2/3 by thrombocytes in response to stimulation with AA was inhibited by aspirin, ibuprofen, and indomethacin.”

“Prostaglandin E2 production by tumour cells was increased in the presence of arachidonic acid and inhibited when indomethacin was present.”

“ Indomethacin inhibited concentration-dependent 8-epi-PGF2alpha formation in platelets stimulated with calcium ionophore, arachidonic acid or thrombin.”

“Moreover, the effect of the arachidonic acid species to stimulate fluid secretion was inhibited by treatment with indomethacin , whereas the effect of the cyst fluid was not.”

“ Arachidonic acid uptake was inhibited by indometacin but not by nordihydroguaiaretic acid, in diabetic as well as in control subjects.”

“4) PG synthesis inhibitors such as indomethacin or flurbiprofen block, or partially inhibit, the reduction of IOP produced by epinephrine, para-aminoclonidine, forskolin, vanadate, verapamil, arachidonic acid , and ALT in rabbits, cats, monkeys, and/or humans.”

“ Indomethacin (3-300 microM) inhibited arachidonic acid-induced aggregation in each species, and collagen responses in all except mouse.”