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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Imipramine
Research Papers that Mention the Interaction
“Compared with chronic saline, chronic imipramine but not bupropion significantly increased cortex cPLA2 mRNA activity, protein and phosphorylation, expression of the cPLA2 transcription factor, activator protein-2α (AP-2α) and AA turnover in phospholipids.”
Chronic imipramine but not bupropion increases arachidonic acid signaling in rat brain: is this related to ‘switching’ in bipolar disorder?“As an extension of this theory, drugs that are thought to induce switching to mania, especially when administered during bipolar depression (fluoxetine and imipramine ), up-regulate enzymes of the arachidonic acid cascade and turnover of arachidonic acid in rat brain phospholipids.”
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