Possible Interaction: Arachidonic Acid and Imidazole

“Synthesis of arachidonic acid metabolites may be manipulated using drugs such as aspirin or imidazole analogues which selectively inhibit different enzymes in the metabolic pathway.”

“Platelet aggregation … by arachidonic acid (0.4 to 0.8 mM) was … significantly less than in matched controls by imidazole , a thromboxane synthetase inhibitor (p < 0.01, n = 11), and 13-azaprostanoic acid, an antagonist of the actions of PGH2 or TXA2 on platelets (p < 0.04, n = 14).”

“ Imidazole , blocked thromboxane synthesis in intact platelets either from arachidonic acid or PGH2, without affecting aggregation.”

“5 Imidazole (50 μm) selectively inhibited conversion of AA to TxA2 and increased conversion to PGI2 in rabbit lungs.”

“Prior treatment with imidazole given intraperitoneally noticeably inhibited the disruption of the blood-aqueous barrier in rabbit eyes induced by topical prostaglandin E2 (PGE)2, topical arachidonic acid (AA), infrared irradiation of the iris, endotoxin of Proteus mirabilis given intravenously, and alpha-melanocyte-stimulating hormone (alpha-MSH) given subcutaneously.”