Possible Interaction: Arachidonic Acid and Ibuprofen

“The production of TXB2/3 by thrombocytes in response to stimulation with AA was inhibited by aspirin, ibuprofen , and indomethacin.”

“In cultured glomerular mesangial (GM), renal papillary collecting tubule (RPCT) and VSM cells from mesenteric artery, indomethacin, tiaprofenic acid, aspirin and ibuprofen inhibited both basal and arachidonic acid (AA)-stimulated PG synthesis dose-dependently.”

“ Ibuprofen is a potent cyclooxygenase inhibitor known to reduce the production of arachidonic acid metabolites.”

“Moreover, the observed synergistic effect of AA with 5-HT on platelets was inhibited by different cyclooxygenase (COX) inhibitors, namely ibuprofen and celecoxib, with half maximal inhibitory effect (IC50) values of 18.0±1.8 and 15.6±3.4 μmol/L, respectively.”

“The most commonly used drugs for this purpose are cyclooxygenase inhibitors, mainly indomethacin and ibuprofen , which block the conversion of arachidonic acid to prostaglandins.”

“ Ibuprofen , but not celecoxib, significantly inhibited TxA2-dependent aggregation, induced ex vivo by arachidonic acid (83 +/- 11% vs. 11.”

“Selective blockade of the different metabolic pathways of arachidonic acid (e.g. ibuprofen for cyclooxygenase, SKF-525A for cytochrome P-450, baicalein and BHPP for 12-lipoxygenase, AA861 and MK886 for 5-lipoxygenase, etc.)”

“The reduction in cyclooxygenase activity, but not arachidonic acid release , was prevented by the presence of ibuprofen during reoxygenation.”

“When enrichment with arachidonic acid was done in the presence of ibuprofen , a reversible cyclooxygenase inhibitor, PGI2 did not accumulate in the medium during supplementation, and the subsequent capacity of the cultures to produce PGI2 in response to thrombin increased by 70% to 240%.”

“pretreatment with ibuprofen , a non-selective COX inhibitor, completely blocked the hyperventilation and blood gases changes induced by AA.”