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“Although hydroperoxides and isoprostanes are major autoxidation products of AA , EETs are also formed from the largely overlooked peroxyl radical addition mechanism.”
Free radical biology & medicine • 2017 | View Paper
“ Hydrogen peroxide (H(2)O(2)) stimulates the release of arachidonic acid from cells, but the signaling mechanism(s) involved remains to be elucidated.”
European journal of pharmacology • 2006 | View Paper
“ Arachidonic and α-linolenic acids treatment enhanced LPS-stimulated H2O2 production by PBMCs, while palmitic, oleic, γ-linolenic, and docosahexaenoic acids did not exert significant effects.”
“Indeed, we found that high concentrations of hydroperoxide activator (e.g. 65 μm) overcame a prolonged lag phase (>1 h) and unveiled a dioxygenase activity with arachidonic acid ; the main products were the 5-, 9-, and 7-hydroperoxyeicosatetraenoic acids (HPETEs).”
“ AA produced toxic effects, especially in the 2E1 cells, and caused a remarkable increase in hydrogen peroxide production and lipid peroxidation compared to the Neo and HepG2 cells.”
Archives of biochemistry and biophysics • 1996 | View Paper
“ H2O2 (0.5 to 5 mumol/L) alone did not influence platelet function, but when it was combined with subthreshold concentrations of arachidonic acid or collagen, it induced platelet aggregation and serotonin release in a dose-dependent fashion.”
“ H2O2 alone did not affect intraplatelet Ca++ influx or mobilization but, combined with subthreshold concentrations of arachidonic acid , it increased Ca++ mobilization.”
The Journal of laboratory and clinical medicine • 1992 | View Paper
“This study suggests that H2O2 triggers the activation of platelets exposed to STC of collagen and arachidonic acid , via the cyclooxygenase pathway.”
“While H2O2 alone did not affect platelet aggregation, it amplified platelet aggregation response in samples stimulated with STC of arachidonic acid and collagen but not in samples stimulated with STC of ADP.”
“Addition of hydrogen peroxide , 15-hydroperoxyeicosatetraenoic acid, or inhibition of the lipoxygenase metabolic pathway by 4,7,10,13-eicosatetraynoic acid also induced a hypersensitive aggregation response to AA.”