Possible Interaction: Arachidonic Acid and Hydrocortisone

“This suppressive effect of cortisol could be reversed by administration of arachidonic acid , which in its own right could stimulate LH release from ovine pituitary tissue.”

“ Arachidonic acid overcame the inhibitory effect of hydrocortisone on PGE production, but failed to restore IFN production in the presence of the steroid.”

“The inhibitory effect of hydrocortisone on slow-reacting substance of anaphylaxis production can be partly reversed by arachidonic acid , which may explain aspirin- and indomethacin-sensitive asthma.”

“ Hydrocortisone inhibits the bradykinin induced increment in cyclic AMP and the release of arachidonic acid and prostaglandins E and F from synovial fibroblasts.”

“Dietary fatty acids, particularly arachidonic acid ARA ), affect cortisol and may influence the expression of genes involved in stress response in fish.”

“Fish reflected dietary ARA content and post-stress cortisol increased with ARA supply up to 1.7 %, whereas 2.3 % ARA seemed to enhance basal cortisol slightly and alter the response to stress.”

“In previous studies in freshwater tilapia (Oreochromis mossambicus), dietary supplementation with arachidonic acid (ArA; 20:4n − 6) had considerable, opposing effects on the main ion-transporting enzyme Na+/K+-ATPase in gills and kidneys and changed the release of osmoregulatory hormones, such as cortisol.”

“ Hydrocortisone (0.5-5 microM) blocks plasma membrane Ca2+ channels and inhibits arachidonic acid-stimulated Ca(2+) influx in JW cells.”

“ Hydrocortisone (10(-7)M - 10(-13)… and absence of added arachidonic acid , resulted in an inhibition of prostaglandins E2 and F2 alpha, and to a lesser extent, 6 keto PGF 1 … only slightly inhibited by the drug in the absence of arachidonic acid and markedly increased in its presence.”

“ Hydrocortisone inhibits both arachidonic acid release and prostaglandin production by L929 cells.”

“ Arachidonic acid completely reversed the hydrocortisone‐ or dexamethasone‐induced inhibition of mitotic activity, but it did so only when it was injected between 2 and 3 hours after partial hepatectomy and glucocorticoid injection.”