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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Arachidonic Acid
drug:
Histamine
Research Papers that Mention the Interaction
“ Histamine also caused a massive release of arachidonic acid , which occurred in a Ca2+‐ and PMA‐sensitive manner, probably through the activation of a cytosolic phospholipase A2, which partly involves coupling to a PTX‐sensitive G protein.”
Guinea Pig Histamine H1 Receptor. II. Stable Expression in Chinese Hamster Ovary Cells Reveals the Interaction with Three Major Signal Transduction Pathways“In addition, histamine induced a biphasic increase in arachidonic acid release.”
“In interphase HeLa cells, incubation with histamine or thapsigargin led to the rapid release of arachidonic acid.”
“On molar basis, the potencies of these arachidonic acid derivatives are respectively about 1000 fold and 30 fold higher than that of histamine.”
“The present study suggests that bradykinin, histamine , and phosphatidic acid may interfere with the distribution and release of arachidonic acid in human keratinocytes in culture.”
“Indomethacin, arachidonic acid , and 5-hydroperoxyeicosatetraenoic acid (5-HPETE) all enhance histamine and LTC4 release from human basophils; no effect is seen with human lung mast cells.”
“ Histamine also caused an increase in extracellular release of arachidonic acid (AA) and formation of glycerophosphoinositol (GPI).”
Homologous desensitization of histamine-mediated signal transduction system in C6 glioma cells.“PGH2 analog (10−4M) and arachidonic acid (10−4M) both inhibited to a similar extent adenylate cyclase stimulated by histamine or by NaF, but not that stimulated by PGE2 or by Gpp(NH)p.”
“ Histamine tended to increase the released amount of radioactive arachidonic acid.”
“It is concluded that metabolites of arachidonic acid possibly mediate the dilating effect of carbachol, acting through muscarine receptors, and of histamine , acting through H1-receptors.”
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