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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Arachidonic Acid and Hesperetin

supplement:

Arachidonic Acid

supplement:

Hesperetin

Research Papers that Mention the Interaction

When arachidonic acid was used for induction of platelet aggregation, a proaggregatory effect was observed for pinocembrin-7-methylether, epicatechin, hesperetin and 3,6-dihydroxyflavone, while the expected antiaggregatory effect was observed only for 6-hydroxyflavone (MINaAC=7.63 μM).
Clinical chemistry and laboratory medicine  •  2012  |  View Paper
Hesperetin concentration-dependently inhibited washed … by collagen and arachidonic acid , with IC50 of 20.5+/-3.5 and 69.2+/-5.1 microM, respectively, while has little effect on thrombin- … (TX) A2 mimic, mediated platelet aggregation, suggesting that hesperetin may selectively inhibit collagen- and arachidonic acid-mediated signal transduction.
In addition, hesperetin inhibited arachidonic acid-mediated platelet aggregation by interfering with cyclooxygenase-1 activity as established by the measurement of arachidonic acid-mediated TXA2 and prostaglandin D2 formations as well as cyclooxygenase-1 and TXA2 synthase activity assays.
Atherosclerosis  •  2007  |  View Paper