Possible Interaction: Arachidonic Acid and Heparin

“There was a significant intraoperative increase in platelet response to arachidonic acid in both groups of patients, which occurred within 3 minutes of administration of unfractionated heparin.”

“ Heparin , when added to citrated platelet-rich plasma (PRP), caused potentiation of platelet aggregation and the release reaction induced by the aggregating agents adenosine diphosphate (ADP), arachidonic acid , collagen, and epinephrine.”

“Timed sequential studies revealed that in the presence of arachidonic acid , the addition of heparin hastened the apparently simultaneous release of both 14C and 3H.”

“OBJECTIVES The administration of unfractionated heparin (UFH) prior to carotid clamping during carotid endarterectomy (CEA) transiently increases the platelet aggregation response to arachidonic acid (AA) despite the use of aspirin.”

“Treatment of CD95‐stimulated T cells with hIIA PLA2 resulted in the release of arachidonic acid but not oleic acid from cells and this release was blocked by heparin and heparinase III.”

“It is also possible that heparin could increase prostaglandin production by activating tissue phospholipase (12) with resultant liberation of arachidonic acid from its phospholipid storage sites.”

“We now report that BALB/cJ BMMC stimulated with KL + IL-10 + IL-1β also exhibit the biphasic release of [… over the first 10 min followed by a delayed phase from 2 to 7 h. The delayed phase of arachidonic acid release … heparin , which concomitantly released … into the supernatant.”

“The hypotensive effect of arachidonic acid in the rabbit increases simultaneously with the fall of the plasmatic unesterified fatty acids (NEFA), after treatment with nicotinic acid or heparin.”

“Blocking this internal Ca2+ release by heparin , in the presence of AA , resulted in abolition of the histamine-induced Ca(2+)-regulated K+ current.”