Possible Interaction: Arachidonic Acid and Gossypol

“ Gossypol , a structurally unrelated inhibitor of calcineurin, was also effective, significantly reducing the efflux of docosahexaenoic, arachidonic and oleic acids.”

“It is therefore possible that both (-) gossypol and (+) gossypol inhibit prostaglandin synthesis at the level of arachidonic acid release.”

“12‐Hydroxyeicosatetraenoic acid (12‐HETE) production from arachidonic acid by cerebral microvessels isolated from perfused adult murine brain was reduced by the lipoxygenase inhibitors baicalein, esculetin, gossypol , nordihydroguaiaretic acid, and quercetin.”