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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Glyburide
Research Papers that Mention the Interaction
“ Arachidonic acid-induced … inhibited by glibenclamide (1 microM, ATP-dependent K(+) channel (K(ATP)) blocker), apamin and charybdotoxin (0.3 microM small (SK(Ca)) and 0.1 microM …(Ca)) conductance Ca(2+)-sensitive K(+) channel blocker, respectively), and 4-aminopyridine (1 mM, voltage-dependent K(+) channel (K(V)) blocker).”
“Glimepiride and glibenclamide inhibited [Ca2+]i elevation induced by arachidonic acid in a dose-dependent manner, whereas gliclazide had no inhibitory effect.”
“Glimepiride and glibenclamide inhibited the formation of small and large aggregates induced by optimal concentrations of arachidonic acid in a dose-dependent manner.”
Sulphonylurea agents inhibit platelet aggregation and [Ca2+]i elevation induced by arachidonic acid.“Using the scrape‐loading technique in cultured astrocytes, … show that sulfonylureas such as tolbutamide and glybenzcyclamide , which inhibit the ATP‐sensitive K+ channel, prevent the inhibition of gap junction permeability caused by several structurally unrelated uncouplers such as oleic acid, arachidonic acid , endothelin‐1, octanol, and α‐glycyrrhetinic acid.”
ATP‐Sensitive Potassium Channel Regulates Astrocytic Gap Junction Permeability by a Ca2+‐Independent Mechanism“In an additional experimental series, the vasodilatation induced by arachidonic acid infusions was found to be significantly reduced in the presence of glibenclamide.”
“ Glyburide (inhibitor of ATP-activated K+ channel) abolished the vasodilator action of AA and BRL 34915.”
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