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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Gliclazide
Research Papers that Mention the Interaction
“ Gliclazide inhibited the formation of small aggregates induced by low concentrations of arachidonic acid to a limited extent.”
Sulphonylurea agents inhibit platelet aggregation and [Ca2+]i elevation induced by arachidonic acid.“ Gliclazide also enhanced the transformation of both arachidonic acid and PGH2 to PGI2 in guinea-pig aorta, indicating that one of the main enhancing sites is the step of converting PGH2 to PGI2.”
Effect of gliclazide on prostaglandin I2 formation in normal and streptozotocin-induced diabetic animals.“ Gliclazide inhibited the thrombin-induced release of radioactive arachidonic acid from [14C] arachidonate-labeled platelets, and the concentration of 50% inhibition (IC50) was 680 μg/ml.”
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