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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Furosemide
Research Papers that Mention the Interaction
“Abstract—Cyclooxygenase metabolites of arachidonic acid modulate the natriuretic effect of furosemide.”
20-HETE and Furosemide-Induced Natriuresis in Salt-Sensitive Essential Hypertension“Incubation with furosemide (10(-4) M) for 30 min caused a marked reduction in both basal and arachidonic acid-stimulated production of PGE2 and PGF2 alpha but did not reduce production of 6-keto-PGF1 alpha and PGD2.”
“ Furosemide at 1 and 2 mM concentrations inhibited ADP- and arachidonic acid induced platelet aggregation.”
“The pulmonary pressor response to a submaximal constrictor dose of arachidonic acid was significantly enhanced by furosemide , however, the pressor response to a maximal constrictor dose of arachidonic acid was attenuated, although not significantly.”
Effect of cyclooxygenase inhibition on the pulmonary vasodilator response to furosemide.“Our data … that furosemide causes a … of arachidonic acid from the kidney from a small pool at fast turnover lipid stores and that the stimulus for arachidonic acid release after furosemide depends on a intra-renal mechanism whereby the diuresis is coupled to the increase in renal blood flow.”
“ Furosemide administration results in an increase in blood flow through the prostaglandin system by causing the release of arachidonic acid from a small pool of lipid stores from the kidney without affecting the total arachidonic acid concentration in the blood.”
“Indomethacin, frusemide , bromcresol green and diethylcarbamazine all decreased biological activation of arachidonic acid.”
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