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Last Updated: 2 years ago

Possible Interaction: Arachidonic Acid and Flurbiprofen

Research Papers that Mention the Interaction

c-fos expression and PGE2 production induced by AA was blocked by a cyclo-oxygenase inhibitor, flurbiprofen , suggesting that PGE2 mediated c-fos induction.
British Journal of Cancer  •  2000  |  View Paper
Flurbiprofen has been shown to inhibit cyclo-oxygenase metabolism of arachidonic acid to thromboxane A2 (TxA2), resulting in the inhibition of platelet aggregation.
This differential effect of flurbiprofen on arachidonic acid metabolism in the platelet is related to differential effects on platelet function.
Prostaglandins, leukotrienes, and essential fatty acids  •  1989  |  View Paper
Treating cells with either methylene blue (20 μm) or the cyclo‐oxygenase inhibitor, flurbiprofen (10 μm), inhibited both resting and arachidonic acid (1 μm)‐induced production of 6‐keto‐PGF1α.
British journal of pharmacology  •  1989  |  View Paper
The addition of arachidonic acid to the superfusing mixture results in an increase in thromboformation; this increasing effect can be blocked completely by prior inhibition of the vessel wall cyclooxygenase activity by inhibitors such as flurbiprofen or indomethacin.
Prostaglandins  •  1985  |  View Paper
A cyclooxygenase inhibitor Flurbiprofen ) prevented this effect of arachidonic acid in the jejunal crypts and in colonic tumors, but not in colonic crypts.
Prostaglandins, leukotrienes, and medicine  •  1984  |  View Paper
All three doses of flurbiprofen prevented both the increase to plasma TB2 concentrations occuring in MI (p less than 0.05) at 2, 3 and 4 hours) and platelet aggregation induced by arachidonic acid.
Research communications in chemical pathology and pharmacology  •  1980  |  View Paper