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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Flurbiprofen
Research Papers that Mention the Interaction
“c-fos expression and PGE2 production induced by AA was blocked by a cyclo-oxygenase inhibitor, flurbiprofen , suggesting that PGE2 mediated c-fos induction.”
Prostaglandin E 2 and the protein kinase A pathway mediate arachidonic acid induction of c-fos in human prostate cancer cells“ Flurbiprofen has been shown to inhibit cyclo-oxygenase metabolism of arachidonic acid to thromboxane A2 (TxA2), resulting in the inhibition of platelet aggregation.”
“This differential effect of flurbiprofen on arachidonic acid metabolism in the platelet is related to differential effects on platelet function.”
“Treating cells with either methylene blue (20 μm) or the cyclo‐oxygenase inhibitor, flurbiprofen (10 μm), inhibited both resting and arachidonic acid (1 μm)‐induced production of 6‐keto‐PGF1α.”
Methylene blue but not changes in cyclic GMP inhibits resting and bradykinin‐stimulated production of prostacyclin by pig aortic endothelial cells“The addition of arachidonic acid to the superfusing mixture results in an increase in thromboformation; this increasing effect can be blocked completely by prior inhibition of the vessel wall cyclooxygenase activity by inhibitors such as flurbiprofen or indomethacin.”
“A cyclooxygenase inhibitor Flurbiprofen ) prevented this effect of arachidonic acid in the jejunal crypts and in colonic tumors, but not in colonic crypts.”
“All three doses of flurbiprofen prevented both the increase to plasma TB2 concentrations occuring in MI (p less than 0.05) at 2, 3 and 4 hours) and platelet aggregation induced by arachidonic acid.”
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