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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Arachidonic Acid and Flurazepam

Research Papers that Mention the Interaction

In addition, flurazepam and not diazepam inhibited the release of arachidonic acid from platelet phospholipids in a concentration dependent manner.
One minute preincubation with flurazepam (3-300 microM) or diazepam (3-300 microM) inhibited platelet aggregation, serotonin secretion and prostaglandin synthesis induced by ADP (1-5 microM), epinephrine (1-5 microM), and arachidonic acid (600-1000 microM).
These findings suggest that: (… C; (b) flurazepam … arachidonic acid , its conversion into prostaglandins and by blocking the action of prostaglandins on platelets; (c) diazepam does not inhibit thrombin-induced …-mediated activation of platelets; and (e) neither diazepam nor flurazepam achieve their antiplatelet actions by affecting platelet cyclic nucleotide levels.
Thrombosis research  •  1985  |  View Paper