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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Fluoxetine
Research Papers that Mention the Interaction
“As an extension of this theory, drugs that are thought to induce switching to mania, especially when administered during bipolar depression fluoxetine and imipramine), up-regulate enzymes of the arachidonic acid cascade and turnover of arachidonic acid in rat brain phospholipids.”
Is the brain arachidonic acid cascade a common target of drugs used to manage bipolar disorder?“Drugs that increase brain cPLA(2) activity (N-methyl-d-aspartic acid and fluoxetine ) are correlated with increased turnover of arachidonic acid in brain phospholipids.”
“ Fluoxetine , a selective serotonin reuptake inhibitor, selectively increased incorporation of arachidonic acid by increasing 5-HT availability in the synaptic cleft and thus indirectly activating phospholipase A2.”
Imaging of brain serotonergic neurotransmission involving phospholipase A2 activation and arachidonic acid release in unanesthetized rats.“ConclusionThe results support the hypothesis that fluoxetine increases the cPLA2-mediated turnover of AA within brain phospholipids.”
“ResultsUsing equations from our fatty acid model, we found that chronic fluoxetine compared with vehicle increased the turnover rate of AA within several brain phospholipids by 75–86%.”
“We hypothesized that chronic fluoxetine would increase the brain activity of PLA2 and the turnover rate of arachidonic acid (AA) in phospholipids of the unanesthetized rat.”
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