Possible Interaction: Arachidonic Acid and Fish Oils

“After 2 weeks several important modifications … fatty acid composition were observed: fish oil induced a significant … linoleic (LA) and arachidonic acid (AA) and a significant increase of eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), while soy … induced significant increases of LA, total polyunsaturated fatty acid (PUFA) and PUFA/SFA ratio.”

“A diet low in arachidonic acid ameliorates clinical signs of inflammation in patients with RA and augments the beneficial effect of fish oil supplementation.”

“OBJECTIVE Since fish oils seem to play a potential role in the treatment of inflammatory disorders by inhibiting arachidonic acid metabolism, the purpose of this study was to determine their therapeutic efficacy in mixed cryoglobulinemia (MC), an inflammatory condition caused by the deposition of immune complexes in vessel walls.”

“… fish oil had increased plasma concentrations of eicosapentaenoic acid (27-fold; 8.5 versus 0.3 g/100 … (34-fold; 5.1 versus 0.1 g/100 g fatty acids; P < .0001), and arachidonic acid (8.3-fold; 4.1 versus 0.… < .0001) compared with horses fed corn oil.”

“The … fish oil caused a dramatic increase (P < 0.01) of all n-3 fatty acids of the yolk, particularly EPA (19.… vs. 0.74 mg/egg) and DHA (143.70 vs. 43.66 mg/egg), and an appreciable decrease of arachidonic acid (25.54 vs. ….72 mg/egg).”

“… fish oil can prevent or reduce this compression increasing the movement of … a competitive substrate for the enzymes that metabolise arachidonic acid ( AA ) to proinflammatory eicosanoids, which is partly how marine omega-3s reduce inflammation.2 … mainly consumed as triglycerides, which are absorbed as free fatty acids and monoglycerides.”

“Dietary intake of fish or fish oil lowers cellular levels of AA and favorably influences eicosanoid metabolism in platelets and leukocytes.”

“The feeding of fish oil has resulted in decreased concentrations of LA and arachidonic (AA) and increased concentrations of n‐3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).”

“Erythrocyte EPA and DHA composition increased, and AA decreased, significantly following low-dose and high-dose FO supplementation.”

“ Fish oil supplementation during pregnancy not only improves maternal and neonatal DHA status, but often reduces γ-linolenic acid (GLA), dihomo-GLA (DGLA), and arachidonic acid ( ARA ) levels also, which may compromise foetal and infant development.”