Possible Interaction: Arachidonic Acid and Fatty Acids, Omega-6

“The n-3 and n-6 fatty acids shunt eicosanoid production away from the arachidonic acid pathway , and hence decrease the production of bronchoconstrictive leukotrienes.”

“Thus there is a positive association between carcinogenesis and dietary intake of both the omega-6 fatty acid precursor linoleic acid and its product arachidonic acid , and a negative association with use of a drug blocking its metabolism to eicosanoids.”

“ Omega-6 fatty acids especially high plasma levels of Arachidonic acid was positively associated with the risk of PC [ORQ1-Q3 = 11.07 (3.50-35.02)].”

“Suggestion that intake of arachidonic acid may be associated with increased SCC incidence and total omega-6 with reduced BCC from our study is still highly uncertain and may be due to chance.”

“… arachidonic acid and … of n-6 fatty acids have been found in many CF cell systems (Carlstedt-Duke et al. 1986; Levistre et al. 1993; Miele et al. 1997; … al. 2000), including an overstimulation of phospholipase A2, the rate-limiting enzyme for arachidonic acid release (Berguerand et al. 1997).”

“Diets deficient in the omega-6 fatty acid linoleic acid reduce arachidonic acid (Ach) concentrations and retard growth of developing animals and humans.”

“These results indicate that the ratio of n-3 to n-6 fatty acids in the diets, rather than the absolute amount of n-3 fatty acids, is the determining factor in inhibiting eicosanoid biosynthesis from AA.”

“The administration of n-6 fatty acid supplements increased AA level in PL, TxB2 production and aggregation only in male platelets.”

“Results demonstrated that diets with higher concentration of omega-6 PUFAS induced an increment of linoleic and arachidonic acid on tumor cell membranes increasing ROS liberation, 12(S)-HHT generation, TP53, Ki67 expression and cell proliferation.”