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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Eugenol
Research Papers that Mention the Interaction
“ Eugenol dose-dependently inhibited 5-HETE (5-hydroxy-5,8,10, 14-eicosatetraenoic acid ) and 15-HETE formation by human polymorphonuclear leucocytes.”
Inhibition of lipoxygenase by phenolic compounds.“Further, eugenol was found to significantly inhibit the formation of LTC(4) in calcium ionophore A23187 and arachidonic acid (AA) stimulated PMNL cells.”
“The derived 1,2-diacetoxy-4-allyl-benzene and eugenol acetate exhibit stronger anti-platelet aggregation activities induced by arachidonic acid than 4-allylcatechol and eugenol, respectively.”
A new aristolactam alkaloid and anti-platelet aggregation constituents from Piper taiwanense.“ Eugenol (3-methoxy-4-hydroxy-propenylbenzene) or sodium eugenol acetate (4-O-acetic acid sodium-3-methoxy-1-propenylbenzene) (0.25, 0.5, 1 mM) concentration-dependently inhibited arachidonic acid (AA)-, collagen-, epinephrine- and ADP-induced platelet aggregation.”
“In experiments using Mn-PHS, eugenol increased the time required for the initiation of O2 consumption after addition of arachidonic acid and also inhibited the rate of O2 uptake.”
“Inhibition by eugenol was highly dependent on arachidonic acid concentration.”
“Pretreatment of rabbits with eugenol (50-100 mg/kg) prevented the lethal effects of intravenous PAF (11 μgg/kg) or AA (2 mg/kg) in a dose-dependent fashion.”
“These results provide evidence that eugenol acts as a dual antagonist of AA and PAF.”
Eugenol: a dual inhibitor of platelet-activating factor and arachidonic acid metabolism.
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