Possible Interaction: Arachidonic Acid and Eicosatrienoic Acid

“Concomitant increases in PGE2 synthesis do not apparently result from an increased production of AA and suggest that DHLA , or a DHLA metabolite, interferes with the metabolism of AA.”

“Besides, the arachidonic acid (AA):dihomo-γ-linolenic acid ratio was 2·01-fold significantly lower in CD patients than in healthy subjects (P< 0·01), underlying an inefficient synthesis of PUFA from their precursors in terms of desaturase activity.”

“… dihomo-γ-linoleic acid increased from d 2 to d 5 of life (p < 0.002), with delta over baseline values of 2.1 ± 0.… 24 h, 3.7 ± 10.9%‰ at 48 h, and 4.4 ± 1.0%‰ at 72 h. 13C content of arachidonic acid tended … insignificantly.”

“In this lipid class, AA and the sum of AA plus its precursor, dihomogamma-linolenic acid , increased significantly with the dose fed.”

“Furthermore, the fatty acid 8,11,14-eicosatrienoic acid , a competitive substrate for arachidonyl-CoA synthetase, totally blocks arachidonic acid uptake into platelets, but, unlike phorbol myristate acetate, does not potentiate arachidonic acid release by Ca2+ ionophores.”

“ Arachidonic acid (AA) is proposed to block the endogenous conversion of dietary linoleic acid to GLA and DGLA , which results in impared cholesterol transport to the liver and increased serum levels.”

“The effects of AA , which stimulated platelet aggregation and increased PF3 activity, were partially counteracted by DHLA after 90 min.”

“ Dihomo-γ-linolenic acid was found to be a mutually competitive substrate with arachidonic acid for the platelet prostaglandin synthetase thus causing reduced utilization of arachidonic acid as shown by measuring the various oxygenation products of arachidonic acid.”

“ Dihomo-gamma-linolenic acid caused a dose-dependent inhibition of chondrocyte proliferation (8% and 35% reduction at 10 and 100 μmol/l respectively) (P<0.01), … by 14% (P<0.01), whilst 100 μmol/l elicited a reduction of 14% (P<0.01); 100 μmol/l of arachidonic acid ….”

“Both arachidonic acid and dihomo-gamma-linolenic acid at 100 μmol/l caused a marked increase in lipid storage which continued even after confluence was achieved.”