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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Arachidonic Acid and Edaravone

Research Papers that Mention the Interaction

Antioxidant actions of edaravone include enhancement of prostacyclin production, inhibition of lipoxygenase metabolism of arachidonic acid by trapping hydroxyl radicals, inhibition of alloxan-induced lipid peroxidation, and quenching of active oxygen, leading to protection of various cells, such as endothelial cells, against damage by reactive oxygen species (ROS).
Recent patents on cardiovascular drug discovery  •  2006  |  View Paper
Arachidonic acid potentiated the activation of soluble guanylate cyclase by lipoxygenase, and this effect was inhibited with nordihydroguairetic acid, 1-phenyl-3-pyrazolidone and hydroquinone, but not with high concentrations of indomethacin, meclofenamate or aspirin.
Prostaglandins  •  1979  |  View Paper