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Last Updated: 5 years ago

Possible Interaction: Arachidonic Acid and Dronedarone

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supplement:

Arachidonic Acid

drug:

Dronedarone

Research Papers that Mention the Interaction

“ Dronedarone , amiodarone and NDBD inhibit rhCYP2J2‐mediated metabolism of AA to 14,15‐EET with Ki values of 3.25, 5.48, 1.39 &mgr;M respectively.”

Effects of dronedarone, amiodarone and their active metabolites on sequential metabolism of arachidonic acid to epoxyeicosatrienoic and dihydroxyeicosatrienoic acids

Biochemical pharmacology • 2017 | View Paper

“For example, dronedarone markedly enhances pilocarpine-stimulated release of arachidonic acid from CHO cells, via the M3 receptor subtype, but does not affect the acetylcholine-stimulated response.”

Dronedarone Modulates M1 and M3 Muscarinic Receptors with Subtype Selectivity, Functional Selectivity, and Probe Dependence

Pharmacology • 2016 | View Paper

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