Possible Interaction: Arachidonic Acid and Dopamine

“The aim of the present study was to see whether other catecholamines--noradrenaline and dopamine --are also capable of modulating arachidonic acid (AA) metabolism in man.”

“Moreover, dopamine may moderate these relationships between AA and cognition.”

“Exogenously added arachidonic acid (20-160 microM) stimulated [3H]dopamine uptake when pre-incubated for short times (15-30 min); 160 microM arachidonic acid inhibited following longer pre-exposures (45-60 min).”

“It is known that arachidonic acid , in addition to promoting release of dopamine , can inhibit its transport.”

“The first is the direct conjugation of arachidonic acid with dopamine and the other is via metabolism of a putative N-arachidonoyl tyrosine (NA-tyrosine).”

“We show that NADA biosynthesis primarily occurs through an enzyme-mediated conjugation of arachidonic acid with dopamine.”

“ AA also increased the turnover of dopamine (DA), noradrenaline (NA), and serotonin (5-HT) in the amygdala and increased the prostaglandin (PG)E(2) level in the hippocampus.”

“It was shown that an insignificant amount of the conjugation products was formed during the incubation of arachidonic acid and dopamine , whereas the substitution of tyrosine for dopamine resulted in the productive biosynthesis of N-arachidonoyldopamine.”

“It was observed that dopamine (DA) one of the most important neurotransmitter in SCG decreases AA uptake into phospholipids of normoxic SCG.”

“Our results show that cannabinoids and arachidonic acid inhibit DA and 5-HT uptake into rat neocortical synaptosomes.”

“We have … that dopamine stimulates the liberation of the …(2) (PGE(2)) precursor, arachidonic acid , in Chinese hamster ovary cells transfected with the rat dopamine D(2) receptor (long isoform), also without … administration of a Ca(2+)-releasing agent [Nilsson et al., Br J Pharmacol 1998;124:1651-8].”