Possible Interaction: Arachidonic Acid and Docosahexaenoic Acid

“ Arachidonic acid (AA) concentrations … response to DHA treatment, while the effect was more pronounced in plasma (wk 0: 183±9.9µg/mL, wk 12: 139±8.0µg/mL, -…<0.001) compared to RBC (wk 0: 130±3.7µg/mL, wk 12: 108±4.0µg/mL, -16%, p=0.001).”

“Increased oral intake of EPA and DHA modifies the content of arachidonic acid as well as of EPA and DHA.”

“EPA and DHA inhibit arachidonic acid metabolism to inflammatory eicosanoids.”

“Docosahexaenoic acid DHA , 22:6n-3) and arachidonic acid (AA, 20:4n-6) have opposite effects on carcinogenesis, with DHA suppressing and AA promoting tumor growth both in vitro and in vivo.”

“ DHA supplementation resulted in increased cellular content of DHA at the cost of AA , which may explain the decreased inflammatory response of cells.”

“ DHA mainly got incorporated at the expense of n-6 arachidonic acid.”

“Higher dietary DHA was reflected in pup cerebrums collected on postnatal days 3 and 31, and levels of arachidonic acid (AA, 20:4n–6) were inversely related to levels of DHA.”

“150, 3525-3533), we described that the enrichment of docosahexaenoic acid DHA , 22:6(n - 3)) reduces both arachidonic acid (AA, 20:4(n - 6)) release and platelet-activating factor (PAF) synthesis in human eosinophilic leukemia cells, Eol-1.”

“ DHA itself had no effect on diameter or adenosine-induced dilation but reduced dilation by AA when coapplied with AA.”

“Dietary supplementation with DHA increased DHA from 7% to ~25% of total phospholipid fatty acids in mitochondrial membranes, and caused a proportional depletion of arachidonic acid (20:4n6).”