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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Dipyridamole
Research Papers that Mention the Interaction
“Direct addition of dipyridamole to vein segments incubated in vitro resulted in a dose-dependent increase in PGI2 production when the incubation was carried out in the presence of arachidonic acid.”
Increased prostacyclin production from human veins by dipyridamole: an in vitro and ex vivo study.“Ex vivo, dipyridamole , aspirin and the combination of these drugs inhibited the platelet aggregation induced by PAF and AA.”
“ Dipyridamole also inhibited arachidonic acid-induced platelet TXA2 generation at these concentrations.”
“ Dipyridamole also inhibited malonyldialdehyde production in response to both thrombin and arachidonic acid.”
“ Dipyridamole potentiated the stimulation of platelet cyclic AMP accumulation by prostacyclin, and also potentiated the stimulatory effect of both arachidonic acid and dihomo-γ-linoleic acid on cyclic GMP accumulation.”
“ Dipyridamole induced a marked increase in the coronary flow and PGI2 formation of the hearts but decreased the enhanced myocardial PGI2 biosynthesis after perfusion with arachidonic acid.”
Myocardial biosynthesis of prostaglandins with special consideration of prostacyclin and the influence of dipyridamole and propranolol.“4 Short infusions of acetylsalicylic acid at low concentrations (2.9 μg/ml), dipyridamole (0.6 μg/ml) and sulphinpyrazone (28.7 μg/ml) selectively inhibited the vasoconstrictor phase of the response to AA.”
“Dipyridamole enhanced the proliferation of these cells in culture and dipyridamole overcame the inhibitory effect of arachidonic acid on cell proliferation.”
“ Dipyridamole , vitamin E and butylated hydroxytoluene inhibited lipid peroxidation both in cultures treated with media alone and in cultures treated with arachidonic acid.”
“The oxygen incorporation into arachidonic acid indicating cyclooxygenase and lipoxydase activity under the influence of lyophilised ram vesicle microsomes was increased by dipyridamole.”
“This could explain partly the detected changes in the pulmonary metabolism of arachidonic acid by dipyridamole.”
“The percentage of arachidonic acid was significantly reduced by dipyridamole , as well as that of different n-3 PUFA present in phospholipid fraction.”
Influence of dipyridamole on the fatty acid composition of the main lipid classes of chick serum.
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