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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Dinoprost
Research Papers that Mention the Interaction
“Moreover, the gene expression levels of EP4 and FP, the respective prostanoid receptors for PGE2 and PGF2α , were gradually suppressed by the supplementation with AA , whereas that of IP for PGI2 remained relatively constant.”
“The treatment of cultured preadipocytes with AA resulted in the decreased synthesis of PGE2 and PGF2α serving as anti-adipogenic PGs although the biosynthesis of pro-adipogenic PGI2 was up-regulated during the differentiation phase.”
Pretreatment of cultured preadipocytes with arachidonic acid during the differentiation phase without a cAMP-elevating agent enhances fat storage after the maturation phase.“The addition of AA (10 to 100 microM) increased both PGE2 and PGF2 alpha release, and simultaneously overcame the inhibition of PGE2 but not PGF2 alpha release by BETA.”
“Perfusion of lung with paraquat or PGF2 alpha , and repeated bolus injection of arachidonic acid or PGE2 caused elevation in both wet weight of lung and Pa. The treatment with alpha-hANP similar to that described above also protected against edema caused by paraquat or arachidonic acid.”
“ Arachidonic acid stimulated both PGE2 and PGF2 alpha synthesis by amnion in both groups.”
“It is concluded that PGF2 alpha and oxytocin promote, by different mechanisms, the release of AA , which in turn may amplify their action by enhancing Ca2+ mobilization from the sarcoplasmic reticulum, thereby fulfilling the role of intracellular signaling molecule in human myometrium.”
“ET-1 (10 and 100 nM) and arachidonic acid (AA, 30 microM), stimulated PGF2 alpha release from proliferative, but not secretory endometrium, by 78%, 86% (P less than 0.01) and 80% respectively, compared with control tissue.”
“The stimulatory effect of PGF2 alpha was saturable and structure-specific and competed with the inhibitory effect of arachidonic acid.”
“In epithelial cell cultures, the increases in PGF2 alpha output obtained with mixtures of E2 and AA were about 2.5-fold greater than the sum of the increases elicited by E2 or AA alone.”
“When mixtures of E2 and AA were added to the cultures of epithelial cells the increase in PGF2 alpha output was 2.5-fold greater than the sum of the increases elicited by E2 or AA alone.”
“2) Administration of arachidonic acid increased the production of PGE2 and PGF2 alpha , but the production of PGs was lower as compared with (A).”
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