supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Diltiazem
Research Papers that Mention the Interaction
“ Diltiazem resulted in significant decrease from baseline in platelet aggregation and ATP release using the arachidonic acid-epinephrine combination (35% and 40% decrease, respectively, p < 0.01) and a significant decrease in aggregation using the arachidonic acid-ADP combination (22% decrease, p < 0.01).”
Effect of diltiazem and low-dose aspirin on platelet aggregation and ATP release induced by paired agonists.“The rank order of potency was nimodipin greater than LU-40883 (verapamil derivative) greater than diltiazem and D-888 (verapamil derivative) greater than verapamil for the ionophore-induced pressure increase, whereas diltiazem was nearly ineffective in the presence of exogenously applied AA.”
Differential influence of calcium channel-blockers on prostanoid generation and thromboxane-mediated vasoconstriction in rabbit lungs.“Treatment of endotoxic rats with a calcium channel blocker, diltiazem , effected an increase in free Ca2+ concentration by IP3 from 124 +/- 18 to 240 +/- 41 nM (P less than 0.01) and by AA from 109 +/- 15 to 192 +/- 32 (P less than 0.01).”
“Results of the present study demonstrate that verapamil and diltiazem inhibit cat or rabbit platelet aggregation induced by ADP, AA , U46619, and PGH2.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback