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Last Updated: 4 months ago

Possible Interaction: Arachidonic Acid and Diethylcarbamazine

Research Papers that Mention the Interaction

Diethylcarbamazine (DEC) interferes with arachidonic acid metabolism for the clearance of microfilariae in Wuchereria bancrofti infected individuals.
Parasitology Research  •  2013  |  View Paper
The interpretation most consistent with existing data is that DEC alters arachidonic acid metabolism in microfilariae and in host endothelial cells.
Parasitology  •  1992  |  View Paper
Diethylcarbamazine (DEC) is a drug that has anti-inflammatory properties due to its effects on the metabolism of arachidonic acid.
Clinical and experimental pharmacology & physiology  •  2015  |  View Paper
Diethylcarbamazine (DEC) is an antifilarial drug with potent anti-inflammatory properties as a result of its interference with the metabolism of arachidonic acid.
Mediators of inflammation  •  2014  |  View Paper
Some pharmacological studies showed that diethylcarbamazine (DEC) interferes with the arachidonic acid metabolism , acting as an anti-inflammatory drug.
European journal of pharmacology  •  2012  |  View Paper
Diethylcarbamazine blocks host, and possibly parasite, enzymes involved in arachidonic acid metabolism , and enhances the innate, nonspecific immune system.
Veterinary journal  •  1997  |  View Paper
This paper reviews sites of action of anthelmintic drugs including: (1) levamisole and pyrantel, which act as agonists at nicotinic acetylcholine receptors of …) the proton ionophores, like closantel, which uncouple oxidative phosphorylation; (7) diamphenethide and clorsulon, which selectively inhibit glucose metabolism of Fasciola and; (8) diethylcarbamazine, … arachidonic acid metabolism ….
Parasitology  •  1997  |  View Paper
D exhibited its inhibitory effect even in presence of exogenous arachidonic acid ( AA ) (16.6 microM) whereas Mf lost its inhibitory effect in presence of AA.
Pretreatment of urethane-anaesthetized rats with D (32 mumol kg-1) but not Mf (7.5 mumol kg-1) for 30 min significantly antagonized AA (4 nmol kg-1)-induced hypotension.
General pharmacology  •  1991  |  View Paper
Indomethacin, frusemide, bromcresol green and diethylcarbamazine all decreased biological activation of arachidonic acid.
The Journal of physiology  •  1979  |  View Paper