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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Dexamethasone
Research Papers that Mention the Interaction
“was potentiated by arachidonic acid (50 μg) and the potentiated response was inhibited by dexamethasone (50 μg, i.pl.)”
Role of lipocortin‐1 in the anti‐hyperalgesic actions of dexamethasone“In contrast, a glucocorticoid such as dexamethasone reduced significantly [3H]arachidonic acid release and arachidonate metabolism induced in both cells.”
“Furthermore, dexamethasone inhibited arachidonic acid (AA) release, suggesting the involvement of phospholipase A2 in PGF2 alpha-induced PG release.”
“The release of [3H]arachidonic acid was inhibited by 40-50% by pretreatment with 1 microM dexamethasone.”
“Further analyses revealed that although Dex did not affect cytosolic phospholipase A(2) (cPLA(2)) expression, it markedly reduced the extent of arachidonic acid (AA) release mediated by peroxynitrite-dependent stimulation of cPLA(2).”
“ Dexamethasone inhibited mRNA and protein expression for mPGES and increased conversion of arachidonic acid to PGE2, but inhibition of mPGES was weaker compared with that of COX-2 in IL-1beta stimulated cells.”
“ Dexamethasone also inhibited stimulated PGE2 output after addition of arachidonic acid.”
“Furthermore, dexamethasone , an inhibitor of phospholipase A2 activity, blocked TPA-induced increases in arachidonic acid release.”
“Pretreatment of cells with dexamethasone (50 nM) for 21 h increased the PGE2 output 6- to 7-fold in 2-h incubations only in the presence of arachidonic acid.”
“In the presence of arachidonic (10(-5) mol/L) or linoleic acids (10(-4) mol/L) in serum-free medium, the addition of dexamethasone (10(-8) mol/L) or cortisol (10(-7) mol/L) suppressed but did not inhibit completely prostacyclin production.”
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