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Possible Interaction: Arachidonic Acid and Cyclosporine

Research Papers that Mention the Interaction

Circulating plasma concentrations of CsA and Tac inhibited CYP2C8 wild-type in vitro epoxidation of AA by 17 and 35%, respectively.
Pharmacogenetics and genomics  •  2008  |  View Paper
Our findings document a key role either for CaN or cPLA 2 expression attenuation and AA release inhibition in the antiapoptotic effect of FK506 and CsA in ischemic astrocytes.
Journal of pharmacological sciences  •  2006  |  View Paper
CsA and LPS both enhance the release of labeled metabolites from cells labeled with arachidonic acid , but indomethacin only blocks the effect of LPS.
These differences are explained by mechanisms in which CsA promotes prostanoid synthesis through arachidonic acid release , and LPS promotes prostanoid synthesis through increased cyclooxygenase activity.
Transplantation  •  1989  |  View Paper
Unlike pyrrophenone, the diacylglycerol analog 1-oleoyl-2-acetyl-sn-glycerol and CsA blocked cell death and arachidonic acid release not by preventing mitochondrial calcium uptake but by inhibiting MPTP formation.
The Journal of biological chemistry  •  2013  |  View Paper
Our findings document a key role either for CaN or cPLA(2) expression attenuation and AA release inhibition in the antiapoptotic effect of FK506 and CsA in ischemic astrocytes.
Journal of pharmacological sciences  •  2006  |  View Paper
cyclosporin A (… arachidonic acid (AA) to 20-HETE (93 +/- 6%, P < 0.05), increased systolic blood pressure (SBP), reduced the urinary excretion of nitrite (53 +/- 8%, P < ….05) and sodium nitroprusside (SNP; 56 +/- 13%, P < 0.05) in the renal preglomerular vessel treated with indomethacin and NO synthase inhibitor.
Journal of hypertension  •  2006  |  View Paper
All these effects of arachidonic acid could be prevented by cyclosporin A but not by the phospholipase A(2) inhibitor aristolochic acid.
The Journal of biological chemistry  •  2000  |  View Paper
CsA induced renal epithelial (LLC-PK1) cell injury (LDH release) as well as lipid peroxidation and degradation (prelabeled 3H arachidonic acid release).
Transplantation  •  1994  |  View Paper
Arachidonic acid omega-hydroxylation activity was also induced 2-fold by treatment with CsA for 17 days.
These data suggest that CsA increased arachidonic acid omega-hydroxylation activity by the induction of CYP4A2.
Biochemical pharmacology  •  1994  |  View Paper
In addition, CSA treatment resulted in i) a reduced acylation of arachidonic acid into medullary phospholipids by 25% and into medullary and cortical triglycerides by 33 and 27%, respectively, and ii) an increase in cortical and medullary triglycerides.
The Journal of pharmacy and pharmacology  •  1990  |  View Paper
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