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Possible Interaction: Arachidonic Acid and Curcumin


Arachidonic Acid

Research Papers that Mention the Interaction

BACKGROUND/AIM Inhibition of arachidonic acid metabolism by curcumin has been suggested to be a key mechanism for its anti-carcinogenic action.
Anticancer research  •  2014  |  View Paper
…,curcumin from C. aromatica, cardamonin, pinocembrine and 5,6-… showed strong inhibition on platelet aggregation induced by AA with IC(50) values of less than 84 microM. Curcumin was the most effective antiplatelet compound … aggregation with IC(50) values of 37.5, 60.9 and 45.7 microM, respectively.
Phytomedicine : international journal of phytotherapy and phytopharmacology  •  2008  |  View Paper
Antiaggregant: curcumin preferentially • inhibits platelet aggregation induced by platelet-activating factor and arachidonic acid in vitro [3].
Expert review of neurotherapeutics  •  2008  |  View Paper
We show that curcumin inhibited platelet aggregation mediated by the platelet agonists epinephrine (200 microM), ADP (4 microM), platelet-activating factor (PAF; 800 nM), collagen (20 microg/mL), and arachidonic acid (AA: 0.75 mM).
Biochemical pharmacology  •  1999  |  View Paper
Its mechanism of action is unknown; curcumin may act by inhibiting arachidonic acid metabolism.
The Journal of laboratory and clinical medicine  •  1997  |  View Paper
Thus, curcuminoids and yakuchinones are more accurately characterized as dual inhibitors of arachidonic acid metabolism.
Prostaglandins, leukotrienes, and medicine  •  1986  |  View Paper
Curcumin is a potent inhibitor of arachidonic acid-induced inflammation in vivo in mouse skin, and this compound is also a potent inhibitor of epidermal lipoxygenase and cyclooxygenase activity in vitro.
Advances in enzyme regulation  •  1991  |  View Paper
At 10 micro M, dibenzoylmethane (DBM), trimethoxydibenzoylmethane (TDM), tetrahydrocurcumin (THC) and curcumin effectively inhibited the release of arachidonic acid and its metabolites in lipopolysaccharide (LPS)-stimulated RAW cells and A23187-stimulated HT-29 cells.
The results suggest that curcumin affects arachidonic acid metabolism by blocking the phosphorylation of cPLA(2), decreasing the expression of COX-2 and inhibiting the catalytic activities of 5-LOX.
Carcinogenesis  •  2004  |  View Paper
Curcumin enhances glutathione content and glutathione-S-transferase activity … liver; and it inhibits lipid peroxidation and arachidonic acid metabolism in mouse skin, protein kinase C activity in TPA-treated NIH 3T3 cells, chemically induced … and tyrosine protein kinase activities in rat colon, and 8-hydroxyguanosine formation in mouse fibroblasts.
Journal of cellular biochemistry. Supplement  •  1995  |  View Paper
Feeding of the curcumin diet caused a significant increase in the concentrations of tetrahydrocurcumin, arachidonic acid and eicosapentaenoic acid and a significant decrease in thiobarbituric acid-reactive substance concentration in serum.
Carcinogenesis  •  1999  |  View Paper
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