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Last Updated: 2 years ago

Possible Interaction: Arachidonic Acid and Curcumin

supplement:

Arachidonic Acid

Research Papers that Mention the Interaction

At 10 micro M, dibenzoylmethane (DBM), trimethoxydibenzoylmethane (TDM), tetrahydrocurcumin (THC) and curcumin effectively inhibited the release of arachidonic acid and its metabolites in lipopolysaccharide (LPS)-stimulated RAW cells and A23187-stimulated HT-29 cells.
The results suggest that curcumin affects arachidonic acid metabolism by blocking the phosphorylation of cPLA(2), decreasing the expression of COX-2 and inhibiting the catalytic activities of 5-LOX.
Carcinogenesis  •  2004  |  View Paper
BACKGROUND/AIM Inhibition of arachidonic acid metabolism by curcumin has been suggested to be a key mechanism for its anti-carcinogenic action.
Anticancer research  •  2015  |  View Paper
…,curcumin from C. aromatica, cardamonin, pinocembrine and 5,6-… showed strong inhibition on platelet aggregation induced by AA with IC(50) values of less than 84 microM. Curcumin was the most effective antiplatelet compound … aggregation with IC(50) values of 37.5, 60.9 and 45.7 microM, respectively.
Phytomedicine : international journal of phytotherapy and phytopharmacology  •  2008  |  View Paper
Antiaggregant: curcumin preferentially • inhibits platelet aggregation induced by platelet-activating factor and arachidonic acid in vitro [3].
Expert review of neurotherapeutics  •  2008  |  View Paper
9 Shah BH, Nawaz Z, Pertani SA et al. Inhibitory effect of curcumin , a food spice from turmeric, on plateletactivating factor and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca signaling.
Anaesthesia  •  2006  |  View Paper
We show that curcumin inhibited platelet aggregation mediated by the platelet agonists epinephrine (200 microM), ADP (4 microM), platelet-activating factor (PAF; 800 nM), collagen (20 microg/mL), and arachidonic acid (AA: 0.75 mM).
Biochemical pharmacology  •  1999  |  View Paper
Its mechanism of action is unknown; curcumin may act by inhibiting arachidonic acid metabolism.
The Journal of laboratory and clinical medicine  •  1997  |  View Paper
Mycelial DGLA levels increased about two-fold (22.3 mg/g dry weight) with a concomitant decrease in AA levels when the fungus was cultivated with curcumin.
Lipids  •  2006  |  View Paper
Feeding of the curcumin diet caused a significant increase in the concentrations of tetrahydrocurcumin, arachidonic acid and eicosapentaenoic acid and a significant decrease in thiobarbituric acid-reactive substance concentration in serum.
Carcinogenesis  •  1999  |  View Paper
Rat … μM curcumin or capsaicin for … incorporation of arachidonic acid into membrane lipids by 82 and 76%: prostaglandin E2 by 45 and 48%; leukotriene B4 by 61 and 46%, and … and 48%, respectively, but did not affect the release of arachidonic acid from macrophages stimulated by phorbol myristate acetate.
Lipids  •  1997  |  View Paper
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