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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
supplement:
Conjugated Linoleic Acid
Research Papers that Mention the Interaction
“COX-1 inhibition was resulting from competition of CLA and linoleic acid with arachidonic acid.”
Prostaglandin E2 (PGE2) and thromboxane A2 (TXA2) synthesis is regulated by conjugated linoleic acids (CLA) in human macrophages.“MDA-MB-231 cells challenged with AA in the presence of all CLA mixtures resulted in significantly reduced PGE2 synthesis relative to controls treated with LA (P < 0.05).”
“Moreover, supplementation with 20 microM LA and 20 microM arachidonic acid profoundly interfered with the inhibitory effect of CLA in HepG2.”
“Both forms of CLA suppressed Wnt signaling and the arachidonic acid cascade in rats treated with beef tallow and AOM.ConclusionThese results suggested that CLA-TG and CLA-FFA suppressed colon carcinogenesis in rats with long-term feeding of a 10% beef tallow diet, through several mechanisms.”
Conjugated linoleic acid suppresses colon carcinogenesis in azoxymethane-pretreated rats with long-term feeding of diet containing beef tallow“In conclusion, fatty liver induced by CLA was attenuated by co-administration with ARA , furthermore, a combination of these fatty acids maintained the anti-obese effect of CLA.”
“In contrast to visceral fat, liver weight was significantly higher in the CLA group than in the control or LA groups, and the effects of CLA were attenuated by ARA.”
“The results also suggested that CLA may inhibit the conversions of C18:0 to C18:1 and C18:2 to C20:4 fatty acid , resulting in significantly lower levels of C18:1 and C20:4 in the livers of the BTC group as compared to the BT group.”
“The results show that feeding the CLA oil reduced the formation of arachidonic acid and eicosanoids but enhanced the formation of long chain (n-3) PUFA and their incorporation into tissue lipids when compared with feeding SFO or HO-SFO.”
“ Arachidonic acid (ARA) content was significantly depressed and linearly related to the addition of CLA to the chicken diet.”
“RAW264.7 macrophages were incubated … added lipid (control), 30 microM AA (AA medium), or 30 microM CLA (CLA medium) for 24 h … with bacterial endotoxin lipopolysaccharide (LPS; 100 ng/ml) for 9 h. CLA significantly depressed PGE(2) and NO production by ….003) and 57% (P=0.0001) respectively.”
“However, dietary CLA decreased mucosal levels of prostaglandin E2, thromboxane B2 and arachidonic acid in a dose-dependent manner.”
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