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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Colchicine
Research Papers that Mention the Interaction
“In the presence of exogenous arachidonic acid (100 microM, 15 min), colchicine decreased LTB4 to 48% +/- 11.7 of control and 5-HETE to 60.5% +/- 5.7 of control (mean +/- SEM); 15-HETE was also decreased to 61% +/- 10.3 of control.”
Colchicine inhibits ionophore-induced formation of leukotriene B4 by human neutrophils: the role of microtubules.“A selective inhibitory effect of colchicine on the 5-LO pathway was demonstrated by monitoring the synthesis of 5-LO products from exogenously supplied AA.”
“In addition, colchicine inhibited the total release of AA as well as prostanoids to a lesser extent.”
Colchicine inhibits arachidonate release and 5-lipoxygenase action in alveolar macrophages.
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