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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Clopidogrel
Research Papers that Mention the Interaction
“Several clinical studies have reported decreased responses to AA in whole blood tests in the presence of clopidogrel.”
Arachidonic acid causes lysis of blood cells and ADP-dependent platelet activation responses in platelet function tests“The … arachidonic acid-induced maximum platelet aggregation ratio (MAR-AA) (aspirin 100 mg) (31.85 ± 12.86 … diphosphate-induced maximum platelet aggregation ratio (MAR-ADP) after the administration of 75 mg clopidogrel for 12 ± 2 days (65.82 ± 10.72 vs. … compared with the no ischemic vascular event group.”
“ASA and clopidogrel significantly reduced platelet aggregation to arachidonic acid and adenosine diphosphate, respectively.”
“Although the patients were not randomized with respect to clopidogrel treatment, multivariate analysis showed that arachidonic acid –induced platelet activation was less in patients receiving clopidogrel.”
“Nevertheless, some patients taking aspirin or clopidogrel showed reduced inhibition of ADP and arachidonic acid induced aggregation in adjusted PRP but not in native PRP.”
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