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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Arachidonic Acid and Clonidine

Research Papers that Mention the Interaction

Pretreatment of cerebral synaptic membranes with arachidonic acid (10 nM-1 microM) at 37 degrees C for 40 min caused a significant increase in [3H]clonidine binding but pretreatment at 4 degrees C did not.
Japanese journal of pharmacology  •  1986  |  View Paper
We conclude that clonidine (but not xylazine) stimulates prostaglandin synthesis possibly by activating phospholipase activity and releasing arachidonic acid from membrane phospholipids.
The Journal of pharmacy and pharmacology  •  1982  |  View Paper
Moreover, the antagonism of the hypotensive effect by inhibitors of PG synthesis suggests that some hypotensive metabolite of arachidonic acid in the brain could be involved in the central hypotensive effect of clonidine.
Prostaglandins  •  1980  |  View Paper