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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Clofibrate
Research Papers that Mention the Interaction
“Although clofibrate has been shown to inhibit platelet aggregation that is caused by thrombin, … release of arachidonic acid from platelet phospholipids [8], here we have demonstrated that clofibrate … arachidonic acid and PLC and reversed the effects of PGE1 on platelet … secretion of [14C]-5HT in similar, concentration-dependent manners.”
Potentiating effects of clofibrate on prostaglandin-dependent and -independent pathways of human platelet activation: evidence for involvement of cyclic AMP.“The arachidonic acid 20-hydroxylase activity is inducible by clofibrate in both liver and kidney, indicating that cytochrome P-450 IVA1 is probably the enzyme responsible for this activity.”
Role of hepatic and renal cytochrome P-450 IVA1 in the metabolism of lipid substrates.“Furthermore, a specific metabolite (or group of metabolites) of arachidonic acid is induced by clofibrate pretreatment and that the formation of this metabolite(s) is inhibited by an antibody to cytochrome P-452.”
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