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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Arachidonic Acid and Clofibrate

Research Papers that Mention the Interaction

Although clofibrate has been shown to inhibit platelet aggregation that is caused by thrombin, … release of arachidonic acid from platelet phospholipids [8], here we have demonstrated that clofibrate … arachidonic acid and PLC and reversed the effects of PGE1 on platelet … secretion of [14C]-5HT in similar, concentration-dependent manners.
Biochemical pharmacology  •  1982  |  View Paper
The arachidonic acid 20-hydroxylase activity is inducible by clofibrate in both liver and kidney, indicating that cytochrome P-450 IVA1 is probably the enzyme responsible for this activity.
Biochemical pharmacology  •  1989  |  View Paper
Furthermore, a specific metabolite (or group of metabolites) of arachidonic acid is induced by clofibrate pretreatment and that the formation of this metabolite(s) is inhibited by an antibody to cytochrome P-452.
Biochemical pharmacology  •  1985  |  View Paper