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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Arachidonic Acid
supplement:
Citicholine
Research Papers that Mention the Interaction
“ Citicoline significantly increased glutathione levels and attenuated release of ArAc and the loss of PtdCho, cardiolipin, and sphingomyelin following transient cerebral ischemia.”
Citicoline mechanisms and clinical efficacy in cerebral ischemia“All the data indicate that the prior injection of CDP-choline stimulates the choline phosphotransferase reaction of brain towards synthesis of phosphatidylcholine and prevents the release of free fatty acids, particularly of arachidonic acid , associated with ischemia.”
Effect of cytidine diphosphate choline (CDP-choline) on ischemia-induced alterations of brain lipid in the gerbil“ Citicoline also significantly attenuated loss of cardiolipin and arachidonic acid release from phosphatidylcholine and phosphatidylethanolamine.”
“Abstract: We have previously demonstrated that cytidine5′‐diphosphocholine (CDP‐choline or citicoline) attenuated arachidonicacid ( ArAc ) release and provided significant protection for the vulnerablehippocampal CA1 neurons of the cornu ammonis after transientforebrain ischemia of gerbil.”
“ CDP‐choline significantly attenuated the blood‐brain barrier (BBB) dysfunction after ischemia with 6‐hr reperfusion, and considerably reduced the increase of AA in FFA and leukotriene C4 (LTC4) synthesis at 1 day.”
“Exogenous treatment with CDP‐choline stimulates PtdCho synthesis and prevents release of free fatty acids (FFA), especially arachidonic acid ( AA ), after ischemia/reperfusion.”
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