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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Chlorpromazine
Research Papers that Mention the Interaction
“ Chlorpromazine , an inhibitor of melatonin-calmodulin interaction, inhibits both ROS and arachidonic acid production, thus possibly placing calmodulin at the origin of a melatonin-induced pro-radical pathway.”
Lipoxygenase-mediated pro-radical effect of melatonin via stimulation of arachidonic acid metabolism.“The dopaminergic blocking agent chlorpromazine behaves like 6-hydroxydopamine and dopamine in blocking epinephrine induced aggregation at lower concentrations but chlorpromazine at higher concentrations also blocks arachidonic acid and ADP induced aggregation.”
“The release of arachidonic acid was found to correlate with the degradation of phosphatidylinositol by the phospholipase A pathway and could be dissociated … the difference in Ca2+ dependence between the two enzymatic processes when zymosan was the stimulus and (iii) by the parallel inhibition by chlorpromazine … arachidonic acid release, ….”
Evidence for a catalytic role of phospholipase A in phorbol diester- and zymosan-induced mobilization of arachidonic acid in mouse peritoneal macrophages.
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