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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Chloroquine
Research Papers that Mention the Interaction
“The effects of chloroquine (100 microM) on leukotriene release were counteracted by the presence of arachidonic acid (10 microM), which suggests that chloroquine had impaired the availability of arachidonate.”
The effects of non-steroidal inhibitors of phospholipase A2 on leukotriene and histamine release from human and guinea-pig lung.“Furthermore, CQ blocks the production of prostaglandins (PGs) in the intact cell by inhibiting substrate accessibility of arachidonic acid necessary for the production of PGs.”
“ Chloroquine is known to inhibit platelet activation by various mechanisms including arachidonic acid liberation from membrane phospholipids.”
“Azithromycin and chloroquine additionally inhibited arachidonic acid release and prostaglandin E2 synthesis.”
Impairment of lysosomal functions by azithromycin and chloroquine contributes to anti-inflammatory phenotype.“ Chloroquine inhibited arachidonic acid liberation from membrane phospholipids of thrombin- and A23187- stimulated platelets.”
“The suppressive action of chloroquine was prevented by addition to the medium of arachidonic acid (2 μg/ml).”
“~ In studies performed in vitro the antiaggregatory effect of chloroquine was found to be time-, dose-, and calcium-dependent and related to inhibition of the arachidonic acid ”
Blood platelets and chloroquine.
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