Possible Interaction: Arachidonic Acid and Celecoxib

“Second, we show that supplying arachidonic acid to increase prostanoid production reduces the effectiveness of both currently used nonsteroidal antiinflammatory drugs (NSAIDs) (diclofenac) and novel COX‐2‐selective inhibitors (NS‐398, celecoxib ) as inhibitors of COX‐2 activity.”

“Moreover, the observed synergistic effect of AA with 5-HT on platelets was inhibited by different cyclooxygenase (COX) inhibitors, namely ibuprofen and celecoxib , with half maximal inhibitory effect (IC50) values of 18.0±1.8 and 15.6±3.4 μmol/L, respectively.”

“The ability of celecoxib , a selective COX-2 inhibitor, to redirect arachidonic acid into the 5-LO pathway can potentially reduce its efficacy as a chemopreventive agent and increase the risk of cardiovascular complications.”

“… celecoxib is a cyclooxygenase-2 (COX-… inhibits the conversion of arachidonic acid to the prostaglandins that mediate pain and inflammation while having no effect on the formation of the prostaglandins that … the gastrointestinal tract, kidneys, and platelets and that are formed under the control of cyclooxygenase-1 (COX-1).”

“Ibuprofen, but not celecoxib , significantly inhibited TxA2-dependent aggregation, induced ex vivo by arachidonic acid (83 +/- 11% vs. 11.”

“Mechanistically, celecoxib and c9t11 disrupt the arachidonic acid cascade ; however, the equivalency of anti-inflammatory effects between these compounds is unknown.”

“The selective cyclooxygenase-2 (COX) inhibitor, celecoxib , and the non-selective COX-1 and COX-2 inhibitor, indomethacin, at microM concentrations, stimulate the release of arachidonic acid from rat liver cells (the C-9 cell line).”

“4 Treatment with the non‐steroidal anti‐inflammatory drugs (NSAIDs), A771726 or diclofenac, or with celecoxib significantly reduced the increase in circulating 6 keto‐PGF1α caused by LPS, and the large increase in 6 keto‐PGF1α following injection of AA.”