Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 4 months ago

Possible Interaction: Arachidonic Acid and Carbachol

Research Papers that Mention the Interaction

Carbamylcholine also increased arachidonic acid release in a concentration-dependent manner.
Endocrine  •  1996  |  View Paper
Stimulation with the cholinergic agonist, carbachol , induces a dose-dependent increase in arachidonic acid release.
Journal of neurochemistry  •  2000  |  View Paper
Dose response curves revealed that carbamylcholine stimulated [3H]AA release by up to 12-fold with an ECo of approximately 0.4 microM; maximal responses were obtained with 10 microM carbamylcholine.
Alcoholism, clinical and experimental research  •  1998  |  View Paper
Carbachol , a muscarinic receptor agonist, stimulated the release of arachidonic acid and inositol phosphates with similar potencies.
Long-term preincubation with PMA or carbachol inhibited PKC activity and prevented carbachol-stimulated release of arachidonic acid , but not inositol phosphates, suggesting that release of arachidonic acid, but not release of inositol phosphates, required activation of PKC.
The Journal of pharmacology and experimental therapeutics  •  1990  |  View Paper
AA concentration-dependently inhibited the effects of carbachol in producing NO (IC50 = 191 μM) but did not alter inositol phosphate production or M1 receptor binding.
Neurochemical Research  •  2002  |  View Paper
Finally, the release of [3H]GABA evoked by the combined application of NMDA and carbachol (a treatment known to markedly stimulate arachidonic acid formation ) was reduced by inhibitors of phospholipase A2 further indicating that endogenously formed arachidonic acid significantly facilitates the release of GABA in the striatum.
Brain Research  •  1996  |  View Paper
In permeabilized ileum smooth muscle maintained at constant [Ca2+] (pCa 6.0), carbachol also significantly increased AA to 1.75 times its original value within 1 min of its application.
The Journal of physiology  •  1995  |  View Paper
The inhibitory effect of arachidonic acid on protein synthesis was duplicated by carbachol , thapsigargin, and BAPTA/AM, three agents that cause net efflux of ER-Ca2+ by different mechanisms.
Journal of dental research  •  1995  |  View Paper
The activation of muscarinic and NMDA receptors by carbachol and NMDA, respectively, stimulated the release of [3H]arachidonic acid ([3H]AA) from cultured striatal neurons.
Journal of neurochemistry  •  1995  |  View Paper
In cultured striatal neurons from embryonic mice, carbachol was found to stimulate the release of arachidonic acid (AA) EC50 = 87 microM) and formation of inositol phosphates (IPs) (EC50 = 54 microM).
The Journal of pharmacology and experimental therapeutics  •  1994  |  View Paper
Show More