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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Carbachol
Research Papers that Mention the Interaction
“Stimulation with the cholinergic agonist, carbachol , induces a dose‐dependent increase in arachidonic acid release.”
Inflammatory Cytokines Enhance Muscarinic‐Mediated Arachidonic Acid Release Through p38 Mitogen‐Activated Protein Kinase in A2058 Cells“ Carbachol , a muscarinic receptor agonist, stimulated the release of arachidonic acid and inositol phosphates with similar potencies.”
“Long-term preincubation with PMA or carbachol inhibited PKC activity and prevented carbachol-stimulated release of arachidonic acid , but not inositol phosphates, suggesting that release of arachidonic acid, but not release of inositol phosphates, required activation of PKC.”
“ AA concentration-dependently inhibited the effects of carbachol in producing NO (IC50 = 191 μM) but did not alter inositol phosphate production or M1 receptor binding.”
Arachidonic Acid Inhibition of Muscarinic Receptor-Mediated Nitric Oxide Production Occurs at the Level of Calcium Mobilization in Chinese Hamster Ovary Cells“It is concluded that metabolites of arachidonic acid possibly mediate the dilating effect of carbachol , acting through muscarine receptors, and of histamine, acting through H1-receptors.”
“Finally, the release of [3H]GABA evoked by the combined application of NMDA and carbachol (a treatment known to markedly stimulate arachidonic acid formation ) was reduced by inhibitors of phospholipase A2 further indicating that endogenously formed arachidonic acid significantly facilitates the release of GABA in the striatum.”
“In permeabilized ileum smooth muscle maintained at constant [Ca2+] (pCa 6.0), carbachol also significantly increased AA to 1.75 times its original value within 1 min of its application.”
“The inhibitory effect of arachidonic acid on protein synthesis was duplicated by carbachol , thapsigargin, and BAPTA/AM, three agents that cause net efflux of ER-Ca2+ by different mechanisms.”
“Abstract: The activation of muscarinic and NMDA receptors by carbachol and NMDA, respectively, stimulated the release of [3H]arachidonic acid ([3H]AA) from cultured striatal neurons.”
“The insulin secretagogues D-glucose and the muscarinic agonist carbachol both increase unesterified arachidonic acid accumulation in isolated islets.”
“In cultured striatal neurons from embryonic mice, carbachol was found to stimulate the release of arachidonic acid (AA) EC50 = 87 microM) and formation of inositol phosphates (IPs) (EC50 = 54 microM).”
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