Possible Interaction: Arachidonic Acid and Capsaicin

“Collagen and arachidonic acid-induced rabbit platelet aggregations were inhibited by SNA and capsaicin.”

“The combination of CAP and DHC produces a significantly greater inhibitory effect on arachidonic acid-induced platelet aggregation and subsequent TXB2 formation, compared with the individual capsaicinoids.”

“Demonstrating that human skin SG in situ and SZ95 sebocytes in vitro express TRPV1, we show that the prototypic TRPV1 agonist, capsaicin , selectively inhibits basal and arachidonic acid-induced lipid synthesis in a dose-, time-, and extracellular calcium-dependent and a TRPV1-specific manner.”

“Co-addition of anandamide or capsaicin synergistically enhanced [3H]arachidonic acid release by mastoparan in the absence of CaCl(2).”

“These findings suggest that anandamide and capsaicin stimulated arachidonic acid metabolism in cannabinoid receptors- and vanilloid VR(1) receptor-independent manner in PC12 cells.”

“Rat peritoneal … curcumin or capsaicin for 1 … of arachidonic acid into membrane lipids by 82 and 76%: prostaglandin E2 by 45 and 48%; leukotriene B4 by 61 and 46%, and … and 48%, respectively, but did not affect the release of arachidonic acid from macrophages stimulated by phorbol myristate acetate.”

“In vitro capsaicin pretreatment reduced the increase in heart rate evoked by AA , whereas it did not affect the increase in coronary flow and decrease in contractility.”

“A sustained downward and rightward displacement of the complete concentration‐response curve to AA was observed after in vitro capsaicin desensitization.”