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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“ Arachidonic acid increased levels of calcium and thromboxane B2, phosphorylation of vasodilator-stimulated phosphoprotein Ser157 and Ser239, and protein kinase Cβ, which were significantly reduced by Alibertia edulis leaf extract, rutin, and caffeic acid as well mixtures of rutin/caffeic acid.”
Rutin present in Alibertia edulis extract acts on human platelet aggregation through inhibition of cyclooxygenase/thromboxane.“These results suggest that early cell death events promoted by an overload of calcium can be prevented by the presence of high levels of arachidonic acid.”
“ Calcium can, however, also modulate the activity of enzymes that produce calcium-mobilising metabolites such as IP3, arachidonic acid and nitric oxide.”
“Stimulation of phosphatidylinositol hydrolysis and arachidonic acid (AA) release displayed markedly cooperative responses to Ca with Hill coefficients of 4-5.”
“ Arachidonic acid induced both Ca2+ (Mn2+) entry through the plasma membrane and Ca2+ release from the intracellular stores.”
“Platelet stimulation with thrombin, adenosine diphosphate, platelet activating factor and arachidonic acid resulted in a concentration-dependent 2.5-3-fold increase in cytoplasmic free calcium concentration over the basal levels (140 +/- 32 nM or 104 +/- 21 respectively) as measured with the fluorescent dyes Quin-2 and Fura-2.”
“Release of arachidonic acid from membrane phospholipids as well as subsequent synthesis and release of vasoconstrictor thromboxane A2 are also regulated by movement of calcium ions.”
“This intracellular rise in calcium is responsible for triggering several cellular responses, including the synthesis of nitric oxide, endothelium-derived hyperpolarizing factor, and eicosanoids derived from arachidonic acid.”
“In B-TECs growing in monolayer, AA induces two different signals: a Ca2+i increase due to Ca2+ entry and an inhibition of store-dependent Ca2+ entry induced by thapsigargin or ATP.”
“Arachidonic acid AA ) modulates intracellular Ca2+ signaling via Ca2+ release or/and Ca2+ entry.”
“By using Fura2/AM, we found that AA induced mobilization of internal Ca2+ store and an increment in Ca2+, Mn2+ and Ba2+ influx in HEK293 cells.”
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