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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
Research Papers that Mention the Interaction
“The steroidogenic induction by AA via PGE2 was mediated in part by Ca2+ since the calcium channel blocker nifedipine (25 microM) inhibited stimulated steroid production by both AA and PGE2.”
Mechanisms of action of free arachidonic acid on ovarian steroid production in the goldfish.“Long-term administration of the slow calcium channel blockers produces another decrease in the content of the bound form of arachidonic acid.”
“The results indicate that (1) endothelial cells spontaneously secrete thromboxane A2, (2) this production can be enhanced severalfold in the presence of arachidonic acid , and (3) the calcium-channel blocker nifedipine significantly inhibits thromboxane production without demonstrable toxicity to the endothelial cells.”
“Treatment of endotoxic rats with a calcium channel blocker , diltiazem, effected an increase in free Ca2+ concentration by IP3 from 124 +/- 18 to 240 +/- 41 nM (P less than 0.01) and by AA from 109 +/- 15 to 192 +/- 32 (P less than 0.01).”
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