Possible Interaction: Arachidonic Acid and Benoxaprofen

“3 AA induced a reduction of histamine elevated perfusion pressure which was inhibited, dose‐dependently, by several non‐steroidal anti‐inflammatory agents including indomethacin, phenylbutazone, aspirin, benoxaprofen , BW755C and phenidone.”

“In contrast, inhibitors of both cyclooxygenase and lipoxygenase Benoxaprofen and BW755c) prevented the effect of arachidonic acid in the colonic crypts and reduced its effect on colonic tumours but did not alter its effect on the jejunum.”

“ Benoxaprofen is an inhibitor pf the lipoxygenase enzyme which converts arachidonic acid to hydroxy derivatives and the leukotrienes.”

“ Benoxaprofen , a new anti-inflammatory agent, has recently been reported to inhibit the production of hydroxy-acid derivatives of arachidonic acid by rabbit PMN lipoxygenase enzymes (Walker & Dawson 1979), whilst possessing relatively low PG cyclo-oxygenase inhibitory activity (Cashin et al 1977).”