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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Astemizole
Research Papers that Mention the Interaction
“In the rabbit small intestine, astemizole O -demethylation was clearly inhibited by ebastine, arachidonic acid , α -naphthoflavone, ketoconazole, tranylcypromine, troglitazone and terfenadine.”
In vitro inhibition of human small intestinal and liver microsomal astemizole O -demethylation: different contribution of CYP2J2 in the small intestine and liver“The CYP2J2 substrates, arachidonic acid and ebastine, strongly inhibited the microsomal astemizole O-demethylation in the human small intestines and recombinant CYP2J2.”
“This study found that the CYP2J2 substrates arachidonic acid (AA) and ebastine strongly inhibited astemizole O-demethylation in microsomes from human small intestines and in in-vitro experiments with recombinant CYP2J2 [6].”
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