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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Aspirin
Research Papers that Mention the Interaction
“In this study, we investigated the efficacies of the cyclo-oxygenase inhibitors aspirin , indomethacin, and piroxicam) and the lipoxygenase inhibitors (N-hydroxy-arachidonamide (AH) and phenidone) in reducing ocular inflammation induced by arachidonic acid.”
Topical arachidonic acid: a model for screening anti-inflammatory agents.“In addition, patients on aspirin have drug-induced abnormalities in platelet response to AA.”
“The estimated glomerular … lower when aspirin resistance was … response to arachidonic acid after 3, 5 and 7 minutes (approximately 30% of patients) (p<0.021), and when defined by response to … after 3 minutes (approximately 17% of patients)(p=0.015) compared to those who were sensitive to aspirin.”
“In conclusion, our results suggest that aspirin ingestion may affect a specific pathway in FA metabolism and that arachidonic acid levels may be related to aspirin intolerance in patients with AIU.”
“… aspirin … arachidonic acid-induced platelet aggregation was significantly larger in the P2Y1 CT893/AG1622 genotype panel (83.4 +/- 3.7%, net reduction by aspirin expressed as … +/- 9.6%) and CC893/AA1622 (65.1 +/- 9.1%) genotypic groups (p = 0.012, 0.025 and 0.004, respectively; statistical power = 77%).”
“Those with diabetes … were sensitive to aspirin inhibition of platelet aggregation … 1.6 mM arachidonic acid (9.5+/-3.9% versus 9.1+/-3.1%, normal range 40-100%) and by 0.83 …/mL collagen (17.4+/-13.9% versus 13.2+/-9.3%, normal range 60-93%), respectively.”
“At both doses ASA completely inhibited the arachidonic acid-induced whole blood platelet aggregation in all healthy donors and in all but 3 IHD patients.”
“ Arachidonic acid and epinephrine promoted a stronger platelet aggregation in aspirin nonresponders than in aspirin responders while taking 300 mg/day aspirin.”
“The NSAIDs, including aspirin , are relatively specific inhibitors of one branch of the arachidonic acid cascade ; this inhibition occurs through cyclooxygenase inhibition, which may modulate carcinogenesis.”
“ Aspirin inhibited platelet aggregation in response to both collagen and arachidonic acid regardless of omeprazole treatment.”
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