Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Arachidonic Acid and Aspirin

supplement:

Arachidonic Acid

drug:

Aspirin

Research Papers that Mention the Interaction

In this study, we investigated the efficacies of the cyclo-oxygenase inhibitors aspirin , indomethacin, and piroxicam) and the lipoxygenase inhibitors (N-hydroxy-arachidonamide (AH) and phenidone) in reducing ocular inflammation induced by arachidonic acid.
Journal of ocular pharmacology  •  1987  |  View Paper
In addition, patients on aspirin have drug-induced abnormalities in platelet response to AA.
The Journal of surgical research  •  2015  |  View Paper
The estimated glomerular … lower when aspirin resistance was … response to arachidonic acid after 3, 5 and 7 minutes (approximately 30% of patients) (p<0.021), and when defined by response to … after 3 minutes (approximately 17% of patients)(p=0.015) compared to those who were sensitive to aspirin.
Thrombosis research  •  2012  |  View Paper
In conclusion, our results suggest that aspirin ingestion may affect a specific pathway in FA metabolism and that arachidonic acid levels may be related to aspirin intolerance in patients with AIU.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology  •  2009  |  View Paper
aspirin … arachidonic acid-induced platelet aggregation was significantly larger in the P2Y1 CT893/AG1622 genotype panel (83.4 +/- 3.7%, net reduction by aspirin expressed as … +/- 9.6%) and CC893/AA1622 (65.1 +/- 9.1%) genotypic groups (p = 0.012, 0.025 and 0.004, respectively; statistical power = 77%).
Pharmacogenomics  •  2007  |  View Paper
Those with diabetes … were sensitive to aspirin inhibition of platelet aggregation … 1.6 mM arachidonic acid (9.5+/-3.9% versus 9.1+/-3.1%, normal range 40-100%) and by 0.83 …/mL collagen (17.4+/-13.9% versus 13.2+/-9.3%, normal range 60-93%), respectively.
Diabetes research and clinical practice  •  2005  |  View Paper
At both doses ASA completely inhibited the arachidonic acid-induced whole blood platelet aggregation in all healthy donors and in all but 3 IHD patients.
Polskie Archiwum Medycyny Wewnetrznej  •  2000  |  View Paper
Arachidonic acid and epinephrine promoted a stronger platelet aggregation in aspirin nonresponders than in aspirin responders while taking 300 mg/day aspirin.
Journal of the Neurological Sciences  •  1999  |  View Paper
The NSAIDs, including aspirin , are relatively specific inhibitors of one branch of the arachidonic acid cascade ; this inhibition occurs through cyclooxygenase inhibition, which may modulate carcinogenesis.
Annals of Internal Medicine  •  1998  |  View Paper
Aspirin inhibited platelet aggregation in response to both collagen and arachidonic acid regardless of omeprazole treatment.
Scandinavian journal of gastroenterology  •  1998  |  View Paper
Show More