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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Aspartate
Research Papers that Mention the Interaction
“Prostaglandin synthase plus arachidonic acid significantly enhanced the ischemia-evoked release of all amino acids ( aspartate 360 fold; glutamate 433 fold; glycine 6 fold; GABA 689 fold; phosphoethanolamine 69 fold) and increased the pre-ischemic levels of glutamate, glycine and phosphoethanolamine.”
Free Radicals and the Ischemia-Evoked Extracellular Accumulation of Amino Acids in Rat Cerebral Cortex“Therefore, AA possibly enhances the extracellular levels of aspartate , glutamate and GABA by inhibiting the uptake of these amino acids and not their efflux.”
“In comparison with untreated animals, arachidonic acid (AA; 5 x 10(-7) M to 5 x 10(-5) M) significantly reduced the ischemia-evoked efflux of glutamate and aspartate into cortical superfusates.”
“They are also consistent with previous evidence that arachidonic acid and/or platelet‐activating factor enhances the release and depresses the uptake of glutamate and aspartate.”
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