Possible Interaction: Arachidonic Acid and Arachidonate

“Chem 264, 3890-3895) reported that the apparent enhanced release of arachidonate was actually due to inhibition of the processes of re-uptake and re-esterification of released arachidonic acid.”

“Preincubation with the arachidonic acid analogue, eicosatetraynoic acid (0.1 mM), which inhibits arachidonate peroxidation, reduced cyclic GMP responses to Ca2+, acetylcholine, noradrenaline and sodium nitroprusside without significant effect on contractile responses.”

“The incorporation of [3H]arachidonate into triglycerides increased at high concentrations of arachidonic or eicosapentaenoic acid, but not at any concentration of oleic or linoleic acid.”

“Uptake of [3H]arachidonate by isolated salivary glands was reduced in the presence of low concentrations of arachidonic or eicosapentaenoic acids, but much higher, non-physiological concentrations of oleic and linoleic acids were required to inhibit [3H]arachidonate uptake.”

“The proportion of [3H]arachidonate incorporated into triglyceride increased at higher media concentrations of arachidonic acid.”

“The concentration-response curve of arachidonic acid exhibited a steep slope, and at higher concentrations arachidonate inhibited enzymatic activity.”

“The inhibitors of lipoxygenase activity, nordihydroguaiaretic acid and eicosatetraynoic acid , had direct effects on soluble guanylate cyclase and interfered with its activation by arachidonate , whereas another lipoxygenase inhibitor, BW 755 C, did not.”

“The fact that PI prevented the edema formation, 1CBF change and the disturbance of blood-brain barrier induced by AA, indicates that peoxidation of AA through the arachidonate cascade is involved in the mechanism of brain edema formation.(ABSTRACT TRUNCATED AT 250 WORDS)”

“Incorporation of labeled arachidonate into these PGs inhibited by indomethacin or eicosatetryenoic acid , and was enhanced by incubation of cells with methylprednisolone, a phospholipase A2 inhibitor, or by using cells from essential fatty acid-deficient rats.”

“In both control and cholesterol-fed groups, methyl arachidonate decreased the proportion of oleic (18:1) and linoleic acids (18:2) and increased arachidonic acid (20:4) content of plasma and liver phospholipid.”